Relationships between the hydrophilic-lipophilic balance values of pharmaceutical excipients and their multidrug resistance modulating effect in Caco-2 cells and rat intestines.
Lo, Yu-li
Relationships between the hydrophilic-lipophilic balance values of pharmaceutical excipients and their multidrug resistance modulating effect in Caco-2 cells and rat intestines. [electronic resource] - Journal of controlled release : official journal of the Controlled Release Society Jun 2003 - 37-48 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
0168-3659
10.1016/s0168-3659(03)00163-9 doi
Adjuvants, Pharmaceutic--chemistry
Animals
Antibiotics, Antineoplastic--pharmacokinetics
Biological Transport--drug effects
Caco-2 Cells
Drug Resistance, Multiple
Drug Resistance, Neoplasm
Electric Conductivity
Epirubicin--pharmacokinetics
Excipients--chemistry
Humans
Ileum--drug effects
In Vitro Techniques
Intestinal Absorption--drug effects
Intestinal Mucosa--metabolism
Intestines--drug effects
Jejunum--drug effects
Male
Rats
Rats, Sprague-Dawley
Relationships between the hydrophilic-lipophilic balance values of pharmaceutical excipients and their multidrug resistance modulating effect in Caco-2 cells and rat intestines. [electronic resource] - Journal of controlled release : official journal of the Controlled Release Society Jun 2003 - 37-48 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
0168-3659
10.1016/s0168-3659(03)00163-9 doi
Adjuvants, Pharmaceutic--chemistry
Animals
Antibiotics, Antineoplastic--pharmacokinetics
Biological Transport--drug effects
Caco-2 Cells
Drug Resistance, Multiple
Drug Resistance, Neoplasm
Electric Conductivity
Epirubicin--pharmacokinetics
Excipients--chemistry
Humans
Ileum--drug effects
In Vitro Techniques
Intestinal Absorption--drug effects
Intestinal Mucosa--metabolism
Intestines--drug effects
Jejunum--drug effects
Male
Rats
Rats, Sprague-Dawley