A selective and oral small molecule inhibitor of vascular epithelial growth factor receptor (VEGFR)-2 and VEGFR-1 inhibits neovascularization and vascular permeability.

Patel, Neela

A selective and oral small molecule inhibitor of vascular epithelial growth factor receptor (VEGFR)-2 and VEGFR-1 inhibits neovascularization and vascular permeability. [electronic resource] - The Journal of pharmacology and experimental therapeutics Sep 2003 - 838-45 p. digital

Publication Type: Journal Article

0022-3565

10.1124/jpet.103.052167 doi


3T3 Cells
Animals
Capillary Permeability--drug effects
Cells, Cultured
Dose-Response Relationship, Drug
Humans
Indoles--pharmacology
Mice
Neovascularization, Pathologic--prevention & control
Propionates--pharmacology
Vascular Endothelial Growth Factor Receptor-1--antagonists & inhibitors
Vascular Endothelial Growth Factor Receptor-2--antagonists & inhibitors