Inhibition of interferon (IFN) gamma-induced Jak-STAT1 activation in microglia by vasoactive intestinal peptide: inhibitory effect on CD40, IFN-induced protein-10, and inducible nitric-oxide synthase expression.

Delgado, Mario

Inhibition of interferon (IFN) gamma-induced Jak-STAT1 activation in microglia by vasoactive intestinal peptide: inhibitory effect on CD40, IFN-induced protein-10, and inducible nitric-oxide synthase expression. [electronic resource] - The Journal of biological chemistry Jul 2003 - 27620-9 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0021-9258

10.1074/jbc.M303199200 doi


Amino Acid Motifs
Animals
Binding Sites
Blotting, Northern
Blotting, Western
CD40 Antigens--metabolism
Cells, Cultured
Central Nervous System--immunology
Chemokine CXCL10
Chemokines, CXC--metabolism
Cyclic AMP--metabolism
Cyclic AMP-Dependent Protein Kinase Type II
Cyclic AMP-Dependent Protein Kinases--metabolism
DNA-Binding Proteins--metabolism
Enzyme Activation
Enzyme-Linked Immunosorbent Assay
Flow Cytometry
Gene Expression Regulation
Humans
Interferon-gamma--antagonists & inhibitors
Janus Kinase 1
Janus Kinase 2
Mice
Mice, Inbred BALB C
Microglia--metabolism
Microscopy, Fluorescence
Models, Biological
Neuropeptides--metabolism
Nitric Oxide Synthase--metabolism
Nitric Oxide Synthase Type II
Oligonucleotides--chemistry
Peptides--chemistry
Phosphorylation
Pituitary Adenylate Cyclase-Activating Polypeptide
Promoter Regions, Genetic
Protein Binding
Protein-Tyrosine Kinases--metabolism
Proto-Oncogene Proteins
RNA, Messenger--metabolism
STAT1 Transcription Factor
Signal Transduction
Time Factors
Trans-Activators--metabolism
Vasoactive Intestinal Peptide--metabolism