Expression of the human CYP3A4 gene in the small intestine of transgenic mice: in vitro metabolism and pharmacokinetics of midazolam.
Granvil, Camille P
Expression of the human CYP3A4 gene in the small intestine of transgenic mice: in vitro metabolism and pharmacokinetics of midazolam. [electronic resource] - Drug metabolism and disposition: the biological fate of chemicals May 2003 - 548-58 p. digital
Publication Type: Journal Article
0090-9556
10.1124/dmd.31.5.548 doi
Administration, Oral
Animals
Area Under Curve
Biological Availability
Blotting, Southern
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme System--genetics
Dexamethasone--pharmacology
Drug Interactions
Enzyme Inhibitors--pharmacology
Half-Life
Humans
In Vitro Techniques
Intestine, Small--metabolism
Ketoconazole--pharmacology
Male
Mice
Mice, Transgenic
Microsomes--drug effects
Midazolam--analogs & derivatives
Polymerase Chain Reaction
Rifampin--pharmacology
Time Factors
Expression of the human CYP3A4 gene in the small intestine of transgenic mice: in vitro metabolism and pharmacokinetics of midazolam. [electronic resource] - Drug metabolism and disposition: the biological fate of chemicals May 2003 - 548-58 p. digital
Publication Type: Journal Article
0090-9556
10.1124/dmd.31.5.548 doi
Administration, Oral
Animals
Area Under Curve
Biological Availability
Blotting, Southern
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme System--genetics
Dexamethasone--pharmacology
Drug Interactions
Enzyme Inhibitors--pharmacology
Half-Life
Humans
In Vitro Techniques
Intestine, Small--metabolism
Ketoconazole--pharmacology
Male
Mice
Mice, Transgenic
Microsomes--drug effects
Midazolam--analogs & derivatives
Polymerase Chain Reaction
Rifampin--pharmacology
Time Factors