Contribution of individual cytochrome P450 isozymes to the O-demethylation of the psychotropic beta-carboline alkaloids harmaline and harmine.

Yu, Ai-Ming

Contribution of individual cytochrome P450 isozymes to the O-demethylation of the psychotropic beta-carboline alkaloids harmaline and harmine. [electronic resource] - The Journal of pharmacology and experimental therapeutics Apr 2003 - 315-22 p. digital

Publication Type: Journal Article

0022-3565

10.1124/jpet.102.047050 doi


Animals
Chromatography, High Pressure Liquid
Cytochrome P-450 Enzyme System--metabolism
DNA, Complementary--genetics
Harmaline--metabolism
Harmine--metabolism
Humans
In Vitro Techniques
Isoenzymes--metabolism
Kinetics
Male
Mass Spectrometry
Methylation
Mice
Mice, Transgenic
Microsomes, Liver--metabolism
Psychotropic Drugs--metabolism