CCAAT/enhancer-binding protein and activator protein-1 transcription factors regulate the expression of interleukin-8 through the mitogen-activated protein kinase pathways in response to mechanical stretch of human airway smooth muscle cells.

Kumar, Ashok

CCAAT/enhancer-binding protein and activator protein-1 transcription factors regulate the expression of interleukin-8 through the mitogen-activated protein kinase pathways in response to mechanical stretch of human airway smooth muscle cells. [electronic resource] - The Journal of biological chemistry May 2003 - 18868-76 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

0021-9258

10.1074/jbc.M212777200 doi


Binding Sites
Biomechanical Phenomena
CCAAT-Binding Factor--antagonists & inhibitors
Calcium--pharmacology
Cells, Cultured
Cyclic AMP-Dependent Protein Kinases--metabolism
Enzyme Activation
Enzyme Inhibitors--pharmacology
Gene Expression Regulation
Humans
Interleukin-1--genetics
Ion Channels--physiology
MAP Kinase Kinase 1
MAP Kinase Kinase 2
Mitogen-Activated Protein Kinase 1--antagonists & inhibitors
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase 8
Mitogen-Activated Protein Kinase Kinases--metabolism
Mitogen-Activated Protein Kinases--antagonists & inhibitors
Muscle Spindles--physiology
Muscle, Smooth--physiology
Phosphatidylinositol 3-Kinases--metabolism
Physical Stimulation
Promoter Regions, Genetic
Protein Kinase C--metabolism
Protein Serine-Threonine Kinases--metabolism
Protein-Tyrosine Kinases--metabolism
RNA, Messenger--analysis
Respiratory System
Reverse Transcriptase Polymerase Chain Reaction
Ribosomal Protein S6 Kinases, 90-kDa--metabolism
Signal Transduction
Transcription Factor AP-1--antagonists & inhibitors
p38 Mitogen-Activated Protein Kinases