Grape seed extract inhibits EGF-induced and constitutively active mitogenic signaling but activates JNK in human prostate carcinoma DU145 cells: possible role in antiproliferation and apoptosis.

Tyagi, Alpana

Grape seed extract inhibits EGF-induced and constitutively active mitogenic signaling but activates JNK in human prostate carcinoma DU145 cells: possible role in antiproliferation and apoptosis. [electronic resource] - Oncogene Mar 2003 - 1302-16 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0950-9232

10.1038/sj.onc.1206265 doi


Adaptor Proteins, Signal Transducing
Adaptor Proteins, Vesicular Transport
Adenocarcinoma--metabolism
Anthracenes--pharmacology
Apoptosis--drug effects
Cell Division--drug effects
Cell-Free System
Culture Media, Serum-Free--pharmacology
DNA-Binding Proteins
Enzyme Inhibitors--pharmacology
Epidermal Growth Factor--antagonists & inhibitors
ErbB Receptors--drug effects
Flavonoids--pharmacology
Humans
JNK Mitogen-Activated Protein Kinases
MAP Kinase Kinase 1
MAP Kinase Signaling System--drug effects
Male
Mitogen-Activated Protein Kinase 1--metabolism
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase Kinases--antagonists & inhibitors
Mitogen-Activated Protein Kinases--antagonists & inhibitors
Neoplasm Proteins--antagonists & inhibitors
Phosphorylation--drug effects
Plant Extracts--pharmacology
Prostatic Neoplasms--metabolism
Protein Processing, Post-Translational--drug effects
Protein Serine-Threonine Kinases--antagonists & inhibitors
Proteins--metabolism
Proto-Oncogene Proteins--metabolism
Seeds--chemistry
Shc Signaling Adaptor Proteins
Signal Transduction--drug effects
Src Homology 2 Domain-Containing, Transforming Protein 1
Transcription Factor AP-1--metabolism
Transcription Factors
Tumor Cells, Cultured--drug effects
Vitis--chemistry
ets-Domain Protein Elk-1