Early mitochondrial hyperpolarization and intracellular alkalinization in lactacystin-induced apoptosis of retinal pigment epithelial cells.

Kim, Jong-M

Early mitochondrial hyperpolarization and intracellular alkalinization in lactacystin-induced apoptosis of retinal pigment epithelial cells. [electronic resource] - The Journal of pharmacology and experimental therapeutics May 2003 - 474-81 p. digital

Publication Type: Journal Article

0022-3565

10.1124/jpet.102.047811 doi


Acetylcysteine--analogs & derivatives
Animals
Apoptosis--drug effects
Blotting, Western
Caspase 3
Caspase Inhibitors
Caspases--biosynthesis
Cell Survival--drug effects
Cells, Cultured
Cysteine Endopeptidases--drug effects
Cysteine Proteinase Inhibitors--pharmacology
DNA--chemistry
Electrophoresis, Polyacrylamide Gel
Electrophysiology
Enzyme Inhibitors--pharmacology
Fluorescent Antibody Technique
Hydrogen-Ion Concentration
Membrane Potentials--drug effects
Microscopy, Electron
Mitochondria--drug effects
Multienzyme Complexes--drug effects
Oligomycins--pharmacology
Pigment Epithelium of Eye--cytology
Poly Adenosine Diphosphate Ribose--biosynthesis
Proteasome Endopeptidase Complex
Proto-Oncogene Proteins--biosynthesis
Proto-Oncogene Proteins c-bcl-2
Rats
bcl-2-Associated X Protein