Indole-3-carbinol inhibits protein kinase B/Akt and induces apoptosis in the human breast tumor cell line MDA MB468 but not in the nontumorigenic HBL100 line.

Howells, Lynne M

Indole-3-carbinol inhibits protein kinase B/Akt and induces apoptosis in the human breast tumor cell line MDA MB468 but not in the nontumorigenic HBL100 line. [electronic resource] - Molecular cancer therapeutics Nov 2002 - 1161-72 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1535-7163


Anticarcinogenic Agents--pharmacology
Apoptosis--drug effects
Breast--cytology
Breast Neoplasms--enzymology
Cell Division--drug effects
DNA, Neoplasm--metabolism
Female
Humans
I-kappa B Kinase
Indoles--pharmacology
Male
NF-kappa B--genetics
Necrosis
PTEN Phosphohydrolase
Phosphatidylinositol 3-Kinases--metabolism
Phosphatidylserines--metabolism
Phosphoric Monoester Hydrolases--metabolism
Phosphorylation
Poly(ADP-ribose) Polymerases--metabolism
Prostatic Neoplasms--metabolism
Protein Serine-Threonine Kinases--metabolism
Proto-Oncogene Proteins--antagonists & inhibitors
Proto-Oncogene Proteins c-akt
Proto-Oncogene Proteins c-bcl-2--metabolism
Signal Transduction--drug effects
Tumor Cells, Cultured
Tumor Suppressor Proteins--metabolism
bcl-2-Associated X Protein
bcl-X Protein