Domain swapping in a COOH-terminal fragment of platelet factor 4 generates potent angiogenesis inhibitors.

Hagedorn, Martin

Domain swapping in a COOH-terminal fragment of platelet factor 4 generates potent angiogenesis inhibitors. [electronic resource] - Cancer research Dec 2002 - 6884-90 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0008-5472


Allantois--blood supply
Amino Acid Sequence
Angiogenesis Inhibitors--chemistry
Animals
Aorta--drug effects
Brain Neoplasms--blood supply
Cattle
Cell Division--drug effects
Cell Movement--drug effects
Chick Embryo
Chorion--blood supply
Endothelial Growth Factors--antagonists & inhibitors
Endothelium, Vascular--cytology
Female
Fibroblast Growth Factor 2--antagonists & inhibitors
Glioma--blood supply
Humans
In Vitro Techniques
Intercellular Signaling Peptides and Proteins--metabolism
Lymphokines--antagonists & inhibitors
Male
Mice
Mice, Nude
Molecular Sequence Data
Neovascularization, Pathologic--drug therapy
Neovascularization, Physiologic--drug effects
Peptide Fragments--chemistry
Platelet Factor 4--chemistry
Protein Structure, Tertiary
Rats
Rats, Sprague-Dawley
Structure-Activity Relationship
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
Xenograft Model Antitumor Assays