Selective alkylation and acylation of alpha and epsilon amino groups with PEG in a somatostatin analogue: tailored chemistry for optimized bioconjugates.

Morpurgo, Margherita

Selective alkylation and acylation of alpha and epsilon amino groups with PEG in a somatostatin analogue: tailored chemistry for optimized bioconjugates. [electronic resource] - Bioconjugate chemistry - 1238-43 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1043-1802

10.1021/bc0100511 doi


Acylation
Alkylation
Amino Acid Sequence
Animals
Cells, Cultured
Chromatography, High Pressure Liquid
Circular Dichroism
Growth Hormone--metabolism
Inhibitory Concentration 50
Male
Molecular Structure
Pituitary Gland, Anterior--cytology
Polyethylene Glycols--chemistry
Rats
Somatostatin--analogs & derivatives
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization