Engagement of glycoprotein IIb/IIIa (alpha(IIb)beta3) on platelets upregulates CD40L and triggers CD40L-dependent matrix degradation by endothelial cells.

May, Andreas E

Engagement of glycoprotein IIb/IIIa (alpha(IIb)beta3) on platelets upregulates CD40L and triggers CD40L-dependent matrix degradation by endothelial cells. [electronic resource] - Circulation Oct 2002 - 2111-7 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1524-4539

10.1161/01.cir.0000033597.45947.0f doi


Blood Platelets--metabolism
CD40 Ligand--biosynthesis
Cell Adhesion
Cells, Cultured
Coculture Techniques
Endothelium, Vascular--enzymology
Extracellular Matrix--metabolism
Humans
Matrix Metalloproteinases--biosynthesis
P-Selectin--biosynthesis
Platelet Glycoprotein GPIIb-IIIa Complex--metabolism
RNA, Messenger--biosynthesis
Up-Regulation