Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis.

Robichaud, Annette

Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis. [electronic resource] - The Journal of clinical investigation Oct 2002 - 1045-52 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0021-9738

10.1172/JCI15506 doi


3',5'-Cyclic-AMP Phosphodiesterases--antagonists & inhibitors
Anesthesia
Animals
Cyclic Nucleotide Phosphodiesterases, Type 4
Male
Mice
Mice, Inbred C57BL
Pentobarbital--pharmacology
Phosphodiesterase Inhibitors--adverse effects
Receptors, Adrenergic, alpha-2--physiology
Time Factors
Vomiting--chemically induced