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Pettersson, F

Retinoids cause apoptosis in pancreatic cancer cells via activation of RAR-gamma and altered expression of Bcl-2/Bax. [electronic resource] - British journal of cancer Aug 2002 - 555-61 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

ISSN: 0007-0920

Standard No.: 10.1038/sj.bjc.6600496 doi

Subjects--Topical Terms:
Adenocarcinoma--genetics
Alitretinoin
Amino Acid Chloromethyl Ketones--pharmacology
Animals
Apoptosis--drug effects
Aspartic Acid--analogs & derivatives
Cysteine Proteinase Inhibitors--pharmacology
DNA Fragmentation--drug effects
Drug Resistance
Fatty Acids, Unsaturated--pharmacology
Gene Expression Regulation, Neoplastic--drug effects
Genes, bcl-2
Humans
Mice
Mitochondria--drug effects
Neoplasm Proteins--biosynthesis
Pancreatic Neoplasms--genetics
Protein Isoforms--drug effects
Proto-Oncogene Proteins--biosynthesis
Proto-Oncogene Proteins c-bcl-2--biosynthesis
Receptors, Retinoic Acid--drug effects
Recombinant Fusion Proteins--physiology
Retinoid X Receptors
Retinoids--agonists
Transcription Factors--drug effects
Transfection
Tretinoin--pharmacology
Tumor Cells, Cultured--drug effects
bcl-2-Associated X Protein
Retinoic Acid Receptor gamma