Role of human MDR1 gene polymorphism in bioavailability and interaction of digoxin, a substrate of P-glycoprotein.

Kurata, Yasuo

Role of human MDR1 gene polymorphism in bioavailability and interaction of digoxin, a substrate of P-glycoprotein. [electronic resource] - Clinical pharmacology and therapeutics Aug 2002 - 209-19 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0009-9236

10.1067/mcp.2002.126177 doi


ATP Binding Cassette Transporter, Subfamily B, Member 1--metabolism
Administration, Oral
Adult
Alleles
Anti-Bacterial Agents--pharmacokinetics
Area Under Curve
Asian People--genetics
Biological Availability
Cardiotonic Agents--pharmacokinetics
Clarithromycin--administration & dosage
Cytochrome P-450 Enzyme System--metabolism
Digoxin--administration & dosage
Drug Administration Schedule
Drug Interactions
Enzyme Inhibitors--pharmacokinetics
Genes, MDR
Genotype
Humans
Injections, Intravenous
Japan
Male
Polymerase Chain Reaction
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Reference Values