Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function.

Basso, Andrea D

Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function. [electronic resource] - The Journal of biological chemistry Oct 2002 - 39858-66 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0021-9258

10.1074/jbc.M206322200 doi


3-Phosphoinositide-Dependent Protein Kinases
Adenosine Triphosphate--metabolism
Animals
Cell Cycle Proteins--metabolism
Chaperonins
Cyclic AMP-Dependent Protein Kinases--metabolism
Cysteine Endopeptidases--metabolism
Down-Regulation
Drosophila Proteins
Female
HSP90 Heat-Shock Proteins--metabolism
Humans
Immunoblotting
Mice
Mice, Inbred BALB C
Microscopy, Fluorescence
Molecular Chaperones--metabolism
Multienzyme Complexes--metabolism
Phosphorylation
Proteasome Endopeptidase Complex
Protein Binding
Protein Serine-Threonine Kinases--metabolism
Protein Structure, Tertiary
Proto-Oncogene Proteins--metabolism
Proto-Oncogene Proteins c-akt
Signal Transduction
Time Factors
Tumor Cells, Cultured