Design, synthesis, and structure-activity relationship of 6-alkynylpyrimidines as potent adenosine kinase inhibitors.

Gomtsyan, Arthur

Design, synthesis, and structure-activity relationship of 6-alkynylpyrimidines as potent adenosine kinase inhibitors. [electronic resource] - Journal of medicinal chemistry Aug 2002 - 3639-48 p. digital

Publication Type: Journal Article

0022-2623

10.1021/jm020049a doi


Adenosine--metabolism
Adenosine Kinase--antagonists & inhibitors
Analgesics--chemical synthesis
Animals
Anti-Inflammatory Agents--chemical synthesis
Enzyme Inhibitors--chemical synthesis
Humans
Magnetic Resonance Spectroscopy
Models, Molecular
Morpholines--chemical synthesis
Pain Measurement
Phosphorylation
Pyridines--chemical synthesis
Pyrimidines--chemical synthesis
Rats
Structure-Activity Relationship
Tumor Cells, Cultured