Pyrrolidine-5,5-trans-lactams as novel mechanism-based inhibitors of human cytomegalovirus protease. Part 3: potency and plasma stability.

Borthwick, Alan D

Pyrrolidine-5,5-trans-lactams as novel mechanism-based inhibitors of human cytomegalovirus protease. Part 3: potency and plasma stability. [electronic resource] - Bioorganic & medicinal chemistry letters Jul 2002 - 1719-22 p. digital

Publication Type: Journal Article

0960-894X

10.1016/s0960-894x(02)00294-9 doi


Antiviral Agents--chemistry
Cytomegalovirus--enzymology
Dansyl Compounds--chemistry
Drug Stability
Half-Life
Humans
Inhibitory Concentration 50
Lactams--blood
Proline--analogs & derivatives
Protease Inhibitors--blood
Pyrrolidines--blood
Spectrometry, Mass, Electrospray Ionization