CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation.

Semplici, Francesca

CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation. [electronic resource] - Oncogene Jun 2002 - 3978-87 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0950-9232

10.1038/sj.onc.1205574 doi


Amino Acid Sequence
Anaphase-Promoting Complex-Cyclosome
Animals
Casein Kinase II
Cells, Cultured
Chloramphenicol O-Acetyltransferase--metabolism
Cloning, Molecular
Cytoskeletal Proteins--metabolism
DNA Primers--chemistry
GTP-Binding Proteins--metabolism
Gene Library
Genetic Complementation Test
Glutathione Transferase--metabolism
Humans
Ligases--genetics
Mice
Molecular Sequence Data
Phosphorylation
Plasmids
Polymerase Chain Reaction
Precipitin Tests
Promoter Regions, Genetic
Protein Serine-Threonine Kinases--metabolism
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Sequence Homology, Amino Acid
Trans-Activators
Ubiquitin--metabolism
Ubiquitin-Conjugating Enzymes
Ubiquitin-Protein Ligase Complexes
beta Catenin
beta-Transducin Repeat-Containing Proteins