4-Hydroxylation of debrisoquine by human CYP1A1 and its inhibition by quinidine and quinine.

Granvil, Camille P

4-Hydroxylation of debrisoquine by human CYP1A1 and its inhibition by quinidine and quinine. [electronic resource] - The Journal of pharmacology and experimental therapeutics Jun 2002 - 1025-32 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0022-3565

10.1124/jpet.301.3.1025 doi


Adrenergic Agents--chemistry
Antimalarials--pharmacology
Cytochrome P-450 CYP1A1--metabolism
Cytochrome P-450 CYP2D6--metabolism
Cytochrome P-450 CYP2D6 Inhibitors
Debrisoquin--chemistry
Dose-Response Relationship, Drug
Enzyme Inhibitors--pharmacology
Humans
Hydroxylation--drug effects
Microsomes--drug effects
Quinidine--pharmacology
Quinine--pharmacology