Nicotinamide modulates mitochondrial membrane potential and cysteine protease activity during cerebral vascular endothelial cell injury.

Chong, Zhao Zhong

Nicotinamide modulates mitochondrial membrane potential and cysteine protease activity during cerebral vascular endothelial cell injury. [electronic resource] - Journal of vascular research - 131-47 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

1018-1172

10.1159/000057762 doi


Animals
Apoptosis--drug effects
Brain--blood supply
Caspase 1--metabolism
Caspase 3
Caspase 8
Caspase 9
Caspases--metabolism
Cell Survival--drug effects
Cells, Cultured
Cysteine Endopeptidases--metabolism
Cytochrome c Group--metabolism
DNA Fragmentation
Endothelium, Vascular--pathology
Free Radicals
In Situ Nick-End Labeling
Intracellular Membranes--drug effects
Membrane Potentials--drug effects
Mitochondria--ultrastructure
Mitogen-Activated Protein Kinases--metabolism
Niacinamide--pharmacology
Nitric Oxide--pharmacology
Phosphatidylserines--metabolism
Phosphorylation
Rats
Rats, Sprague-Dawley