Inhibition of tyrosine kinases blocks adhesion-induced T-cell coactivation without interfering with T-cell adhesion to endothelial cell-surface ligands.

Nowlin, Dawn M

Inhibition of tyrosine kinases blocks adhesion-induced T-cell coactivation without interfering with T-cell adhesion to endothelial cell-surface ligands. [electronic resource] - Inflammation Feb 2002 - 31-43 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0360-3997

10.1023/a:1014421829234 doi


Antibodies, Monoclonal--pharmacology
CD3 Complex--immunology
Cell Adhesion--drug effects
Cell Adhesion Molecules--metabolism
Dose-Response Relationship, Drug
Endothelium--chemistry
Enzyme Inhibitors--pharmacology
Humans
Interleukin-2--biosynthesis
Lymphocyte Activation--drug effects
Mitogen-Activated Protein Kinase Kinases--antagonists & inhibitors
Protein-Tyrosine Kinases--antagonists & inhibitors
Signal Transduction
T-Lymphocytes--cytology