A presenilin 1 mutation associated with familial frontotemporal dementia inhibits gamma-secretase cleavage of APP and notch.

Amtul, Zareen

A presenilin 1 mutation associated with familial frontotemporal dementia inhibits gamma-secretase cleavage of APP and notch. [electronic resource] - Neurobiology of disease Mar 2002 - 269-73 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

0969-9961

10.1006/nbdi.2001.0473 doi


Amyloid Precursor Protein Secretases
Amyloid beta-Protein Precursor--metabolism
Animals
CHO Cells
Cricetinae
Dementia--genetics
Endopeptidases--metabolism
Glioma
Membrane Proteins--genetics
Mutation
Phenotype
Presenilin-1
Receptors, Notch
Tumor Cells, Cultured