Design and synthesis of a novel and potent series of inhibitors of cytosolic phospholipase A(2) based on a 1,3-disubstituted propan-2-one skeleton.

Connolly, Stephen

Design and synthesis of a novel and potent series of inhibitors of cytosolic phospholipase A(2) based on a 1,3-disubstituted propan-2-one skeleton. [electronic resource] - Journal of medicinal chemistry Mar 2002 - 1348-62 p. digital

Publication Type: Journal Article

0022-2623

10.1021/jm011050x doi


Arachidonic Acid--analysis
Cytosol--enzymology
Drug Design
Enzyme Inhibitors--chemical synthesis
HL-60 Cells--drug effects
Humans
Ketones--chemical synthesis
Lipid Bilayers--metabolism
Phospholipases A--antagonists & inhibitors
Propane--analogs & derivatives
Structure-Activity Relationship