Signal pathways involved in activation of p70S6K and phosphorylation of 4E-BP1 following exposure of multiple myeloma tumor cells to interleukin-6.

Shi, Yijiang

Signal pathways involved in activation of p70S6K and phosphorylation of 4E-BP1 following exposure of multiple myeloma tumor cells to interleukin-6. [electronic resource] - The Journal of biological chemistry May 2002 - 15712-20 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

0021-9258

10.1074/jbc.M200043200 doi


Adaptor Proteins, Signal Transducing
Androstadienes--pharmacology
Carrier Proteins--metabolism
Cell Cycle Proteins
Enzyme Activation
Enzyme Inhibitors--pharmacology
Flavonoids--pharmacology
Humans
Insulin-Like Growth Factor I--pharmacology
Interleukin-6--pharmacology
Kinetics
MAP Kinase Signaling System--drug effects
Multiple Myeloma
Phosphatidylinositol 3-Kinases--metabolism
Phosphoproteins--metabolism
Phosphorylation
Protein Serine-Threonine Kinases
Proto-Oncogene Proteins--metabolism
Proto-Oncogene Proteins c-akt
Recombinant Proteins--pharmacology
Repressor Proteins--metabolism
Ribosomal Protein S6 Kinases--metabolism
Signal Transduction--drug effects
Sirolimus--pharmacology
Tumor Cells, Cultured
Wortmannin