Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling.

Lawrenson, Isobel D

Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling. [electronic resource] - Journal of cell science Mar 2002 - 1059-72 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0021-9533

10.1242/jcs.115.5.1059 doi


Actin Cytoskeleton--drug effects
Cell Adhesion--drug effects
Cell Membrane--drug effects
Cell Size--drug effects
Ephrin-A5
Gene Expression Regulation, Neoplastic--physiology
Humans
Melanoma--metabolism
Membrane Proteins--metabolism
Mutation--physiology
Phosphotransferases--metabolism
Protein Kinases--metabolism
Protein Structure, Tertiary--genetics
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-crk
Pseudopodia--drug effects
Receptor Protein-Tyrosine Kinases--drug effects
Receptor, EphA7
Tumor Cells, Cultured
Tyrosine--genetics
rho GTP-Binding Proteins--metabolism