Diverse effects of mutations in exon II of the von Hippel-Lindau (VHL) tumor suppressor gene on the interaction of pVHL with the cytosolic chaperonin and pVHL-dependent ubiquitin ligase activity.

Hansen, William J

Diverse effects of mutations in exon II of the von Hippel-Lindau (VHL) tumor suppressor gene on the interaction of pVHL with the cytosolic chaperonin and pVHL-dependent ubiquitin ligase activity. [electronic resource] - Molecular and cellular biology Mar 2002 - 1947-60 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0270-7306

10.1128/MCB.22.6.1947-1960.2002 doi


Carcinoma, Renal Cell--genetics
Cell Cycle Proteins--metabolism
Chaperonin Containing TCP-1
Chaperonins--metabolism
Cullin Proteins
Elongin
Exons--physiology
Humans
Hypoxia-Inducible Factor 1, alpha Subunit
Ligases--genetics
Macromolecular Substances
Mutagenesis, Site-Directed
Mutation
Protein Binding--drug effects
Protein Folding
Structure-Activity Relationship
Transcription Factors--metabolism
Transfection
Tumor Cells, Cultured
Tumor Suppressor Proteins
Ubiquitin--metabolism
Ubiquitin-Protein Ligases
Von Hippel-Lindau Tumor Suppressor Protein