Drug metabolic activity of cultured hepatocytes can synchronize with bile acid concentration in the medium.

Sugihara, Nobuhiro

Drug metabolic activity of cultured hepatocytes can synchronize with bile acid concentration in the medium. [electronic resource] - Cell biochemistry and function Mar 2002 - 11-7 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0263-6484

10.1002/cbf.933 doi


Aminopyrine N-Demethylase--metabolism
Animals
Aryl Hydrocarbon Hydroxylases
Bile Acids and Salts--metabolism
Biological Clocks
Cells, Cultured
Culture Media
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme System--metabolism
Glycocholic Acid--pharmacology
Hepatocytes--drug effects
Kinetics
Male
Mice
Mice, Inbred ICR
Oxidoreductases, N-Demethylating--metabolism
RNA, Messenger--metabolism