The impact of P-glycoprotein efflux on enterocyte residence time and enterocyte-based metabolism of verapamil.

Johnson, B M

The impact of P-glycoprotein efflux on enterocyte residence time and enterocyte-based metabolism of verapamil. [electronic resource] - The Journal of pharmacy and pharmacology Dec 2001 - 1611-9 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0022-3573

10.1211/0022357011778214 doi


ATP Binding Cassette Transporter, Subfamily B, Member 1--metabolism
Animals
Aryl Hydrocarbon Hydroxylases
Calcium Channel Blockers--metabolism
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme System--physiology
Dose-Response Relationship, Drug
Enterocytes--metabolism
Male
Oxidoreductases, N-Demethylating--physiology
Rats
Rats, Sprague-Dawley
Time Factors
Verapamil--metabolism