Phe(303) in TMVI of the alpha(1B)-adrenergic receptor is a key residue coupling TM helical movements to G-protein activation.

Chen, Songhai

Phe(303) in TMVI of the alpha(1B)-adrenergic receptor is a key residue coupling TM helical movements to G-protein activation. [electronic resource] - Biochemistry Jan 2002 - 588-96 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0006-2960

10.1021/bi011868k doi


Amino Acid Sequence
Animals
Binding Sites
COS Cells
Cell Membrane--metabolism
Cricetinae
Cysteine--chemistry
Cytoplasm--metabolism
Dose-Response Relationship, Drug
Epinephrine--chemistry
GTP-Binding Proteins--chemistry
Humans
Hydrogen-Ion Concentration
Hydrolysis
Ligands
Molecular Sequence Data
Mutagenesis, Site-Directed
Mutation
Phenylalanine--chemistry
Phosphatidylinositols--metabolism
Protein Binding
Receptors, Adrenergic, alpha-1--chemistry
Sequence Homology, Amino Acid
Signal Transduction
Temperature
Time Factors
Transfection