Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages.

Coxon, F P

Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages. [electronic resource] - The Journal of biological chemistry Dec 2001 - 48213-22 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0021-9258

10.1074/jbc.M106473200 doi


Alkyl and Aryl Transferases--antagonists & inhibitors
Animals
Cell Line
Diphosphonates--pharmacology
Enzyme Inhibitors--pharmacology
Macrophages--drug effects
Microscopy, Electron
Osteoclasts--drug effects
Protein Prenylation
Pyridines--pharmacology
Rabbits