NSAIDs inhibit alpha V beta 3 integrin-mediated and Cdc42/Rac-dependent endothelial-cell spreading, migration and angiogenesis.

Dormond, O

NSAIDs inhibit alpha V beta 3 integrin-mediated and Cdc42/Rac-dependent endothelial-cell spreading, migration and angiogenesis. [electronic resource] - Nature medicine Sep 2001 - 1041-7 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1078-8956

10.1038/nm0901-1041 doi


Animals
Anti-Inflammatory Agents, Non-Steroidal--pharmacology
Cell Division--drug effects
Cell Movement--drug effects
Cells, Cultured
Cyclooxygenase 2
Cyclooxygenase 2 Inhibitors
Cyclooxygenase Inhibitors--pharmacology
Dinoprostone--pharmacology
Endothelium, Vascular--cytology
Fibroblast Growth Factor 2--pharmacology
Humans
Isoenzymes--antagonists & inhibitors
Membrane Proteins
Mice
Mice, Nude
Neovascularization, Physiologic--drug effects
Nitrobenzenes--pharmacology
Prostaglandin-Endoperoxide Synthases
Receptors, Vitronectin--antagonists & inhibitors
Sulfonamides--pharmacology
Thromboxane A2--pharmacology
cdc42 GTP-Binding Protein--drug effects
rac GTP-Binding Proteins--drug effects