Simvastatin induces regression of cardiac hypertrophy and fibrosis and improves cardiac function in a transgenic rabbit model of human hypertrophic cardiomyopathy.

Patel, R

Simvastatin induces regression of cardiac hypertrophy and fibrosis and improves cardiac function in a transgenic rabbit model of human hypertrophic cardiomyopathy. [electronic resource] - Circulation Jul 2001 - 317-24 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

1524-4539

10.1161/hc2801.094031 doi


Animals
Animals, Genetically Modified
Cardiomegaly--complications
Cardiomyopathy, Hypertrophic--complications
Cell Line
Disease Models, Animal
Echocardiography
Echocardiography, Doppler
Endomyocardial Fibrosis--complications
Hydroxymethylglutaryl-CoA Reductase Inhibitors--administration & dosage
Hypolipidemic Agents--administration & dosage
Mitogen-Activated Protein Kinase 1--metabolism
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinases--metabolism
Mutation
Myocardium--metabolism
Myosin Heavy Chains--genetics
Phenotype
Rabbits
Remission Induction
Simvastatin--administration & dosage
Ventricular Function, Left--drug effects
ras Proteins--metabolism
rhoA GTP-Binding Protein--metabolism