Toxicity and toxicokinetics of a phosphorothioate oligonucleotide against the c-myc oncogene in cynomolgus monkeys.

Webb, M S

Toxicity and toxicokinetics of a phosphorothioate oligonucleotide against the c-myc oncogene in cynomolgus monkeys. [electronic resource] - Antisense & nucleic acid drug development Jun 2001 - 155-63 p. digital

Publication Type: Journal Article

1087-2906

10.1089/108729001300338681 doi


Animals
Base Sequence
Blood Coagulation--drug effects
Complement Activation--drug effects
Drug Evaluation, Preclinical
Female
Genes, myc
In Vitro Techniques
Kidney Tubules--drug effects
Kupffer Cells--drug effects
Lymph Nodes--drug effects
Macaca fascicularis--genetics
Male
Molecular Structure
Nucleic Acid Conformation
Oligodeoxyribonucleotides, Antisense--chemistry
Oligonucleotides--chemistry
Partial Thromboplastin Time
Safety
Thionucleotides--chemistry