Systemic IFN-beta gene therapy results in long-term survival in mice with established colorectal liver metastases.

Tada, H

Systemic IFN-beta gene therapy results in long-term survival in mice with established colorectal liver metastases. [electronic resource] - The Journal of clinical investigation Jul 2001 - 83-95 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0021-9738

10.1172/JCI9841 doi


Adenocarcinoma--drug therapy
Adenoviridae--genetics
Animals
Apoptosis
Colorectal Neoplasms--pathology
Cytomegalovirus--genetics
DNA, Complementary--administration & dosage
Female
Genes, Synthetic
Genetic Therapy
Genetic Vectors--administration & dosage
Hepatocytes--metabolism
Humans
Injections, Intraperitoneal
Injections, Intravenous
Interferon-beta--administration & dosage
Killer Cells, Natural--drug effects
Liver Neoplasms--drug therapy
Macrophages--drug effects
Mice
Mice, Inbred BALB C
Mice, Nude
Mice, SCID
Neoplasm Transplantation
Neovascularization, Pathologic--drug therapy
Promoter Regions, Genetic
Recombinant Fusion Proteins--administration & dosage
Tumor Cells, Cultured--transplantation
Xenograft Model Antitumor Assays