T cell-specific loss of Pten leads to defects in central and peripheral tolerance.

Suzuki, A

T cell-specific loss of Pten leads to defects in central and peripheral tolerance. [electronic resource] - Immunity May 2001 - 523-34 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1074-7613

10.1016/s1074-7613(01)00134-0 doi


Animals
Apoptosis--immunology
CD4-Positive T-Lymphocytes--cytology
Cell Division
Cytokines--biosynthesis
DNA-Binding Proteins--metabolism
Enterotoxins--immunology
Female
Genes, Tumor Suppressor
I-kappa B Proteins
Immune Tolerance
Lymphatic Diseases--immunology
Lymphoma, T-Cell--immunology
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
Mitogen-Activated Protein Kinases--metabolism
PTEN Phosphohydrolase
Phosphoric Monoester Hydrolases--genetics
Protein Serine-Threonine Kinases
Proto-Oncogene Proteins--metabolism
Proto-Oncogene Proteins c-akt
Proto-Oncogene Proteins c-bcl-2--metabolism
Receptors, Antigen--genetics
Receptors, Antigen, T-Cell--genetics
Splenomegaly
Staphylococcus aureus--immunology
Superantigens--immunology
Thymus Gland--abnormalities
Tumor Suppressor Proteins