Biochemical characterization of the gamma-secretase activity that produces beta-amyloid peptides.

Zhang, L

Biochemical characterization of the gamma-secretase activity that produces beta-amyloid peptides. [electronic resource] - Biochemistry Apr 2001 - 5049-55 p. digital

Publication Type: Journal Article

0006-2960

10.1021/bi0028800 doi


Alzheimer Disease--enzymology
Amyloid Precursor Protein Secretases
Amyloid beta-Peptides--antagonists & inhibitors
Aspartic Acid Endopeptidases
Brefeldin A--pharmacology
Cell Line
Cell Membrane--enzymology
Cell-Free System
Endopeptidases--chemistry
Enzyme Activation--drug effects
Humans
Hydrolysis
Leupeptins--pharmacology
Membrane Proteins--antagonists & inhibitors
Oligopeptides--pharmacology
Peptide Fragments--antagonists & inhibitors
Protease Inhibitors--pharmacology
Protein Transport--drug effects
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Substrate Specificity