[(35)S]GTPgammaS autoradiography reveals a wide distribution of G(i/o)-linked ADP receptors in the nervous system: close similarities with the platelet P2Y(ADP) receptor.

Laitinen, J T

[(35)S]GTPgammaS autoradiography reveals a wide distribution of G(i/o)-linked ADP receptors in the nervous system: close similarities with the platelet P2Y(ADP) receptor. [electronic resource] - Journal of neurochemistry Apr 2001 - 505-18 p. digital

Publication Type: Journal Article

0022-3042

10.1046/j.1471-4159.2001.00265.x doi


Adenine Nucleotides--pharmacology
Adenosine--analogs & derivatives
Adenosine Diphosphate--pharmacology
Adenosine Triphosphatases--antagonists & inhibitors
Adenosine Triphosphate--analogs & derivatives
Adrenal Medulla--chemistry
Animals
Autoradiography
Blood Platelets--chemistry
Brain--blood supply
Brain Chemistry
Capillaries--cytology
Cell Line
Dithiothreitol--pharmacology
Endothelium, Vascular--chemistry
Enzyme Activation--drug effects
Enzyme Inhibitors--pharmacology
GTP-Binding Protein alpha Subunits, Gi-Go--analysis
Glioma--pathology
Guanosine 5'-O-(3-Thiotriphosphate)--analysis
Heterotrimeric GTP-Binding Proteins--analysis
Macromolecular Substances
Magnetic Resonance Spectroscopy
Male
Membrane Proteins
Nerve Tissue Proteins--antagonists & inhibitors
Neuroglia--chemistry
Organ Specificity
Rats
Rats, Wistar
Receptors, Purinergic P2--analysis
Receptors, Purinergic P2Y12
Signal Transduction
Sulfhydryl Reagents--pharmacology
Sulfur Radioisotopes--analysis
Thionucleotides--pharmacology
Tumor Cells, Cultured
Uracil Nucleotides--pharmacology
Xanthines--metabolism