Identification of amino acid residues responsible for the alpha5 subunit binding selectivity of L-655,708, a benzodiazepine binding site ligand at the GABA(A) receptor.
Casula, M A
Identification of amino acid residues responsible for the alpha5 subunit binding selectivity of L-655,708, a benzodiazepine binding site ligand at the GABA(A) receptor. [electronic resource] - Journal of neurochemistry Apr 2001 - 445-51 p. digital
Publication Type: Comparative Study; Journal Article
0022-3042
10.1046/j.1471-4159.2001.00289.x doi
Amino Acid Sequence
Amino Acid Substitution
Animals
Anti-Anxiety Agents--metabolism
Azides--metabolism
Benzodiazepines--metabolism
Binding Sites
Binding, Competitive
Carbolines--metabolism
DNA, Complementary
Female
Flumazenil--metabolism
Flunitrazepam--metabolism
GABA-A Receptor Agonists
Humans
Imidazoles--metabolism
Isoleucine--chemistry
Ligands
Molecular Sequence Data
Mutagenesis, Site-Directed
Oocytes
Protein Binding
Protein Structure, Tertiary
Protein Subunits
Pyridazines--metabolism
Pyridines--metabolism
Receptors, GABA-A--chemistry
Recombinant Fusion Proteins--chemistry
Sequence Alignment
Structure-Activity Relationship
Threonine--chemistry
Transfection
Xenopus laevis
Zolpidem
Identification of amino acid residues responsible for the alpha5 subunit binding selectivity of L-655,708, a benzodiazepine binding site ligand at the GABA(A) receptor. [electronic resource] - Journal of neurochemistry Apr 2001 - 445-51 p. digital
Publication Type: Comparative Study; Journal Article
0022-3042
10.1046/j.1471-4159.2001.00289.x doi
Amino Acid Sequence
Amino Acid Substitution
Animals
Anti-Anxiety Agents--metabolism
Azides--metabolism
Benzodiazepines--metabolism
Binding Sites
Binding, Competitive
Carbolines--metabolism
DNA, Complementary
Female
Flumazenil--metabolism
Flunitrazepam--metabolism
GABA-A Receptor Agonists
Humans
Imidazoles--metabolism
Isoleucine--chemistry
Ligands
Molecular Sequence Data
Mutagenesis, Site-Directed
Oocytes
Protein Binding
Protein Structure, Tertiary
Protein Subunits
Pyridazines--metabolism
Pyridines--metabolism
Receptors, GABA-A--chemistry
Recombinant Fusion Proteins--chemistry
Sequence Alignment
Structure-Activity Relationship
Threonine--chemistry
Transfection
Xenopus laevis
Zolpidem