Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing.

Soriano, S

Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing. [electronic resource] - The Journal of cell biology Feb 2001 - 785-94 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

0021-9525

10.1083/jcb.152.4.785 doi


Alzheimer Disease
Amyloid Precursor Protein Secretases
Amyloid beta-Protein Precursor--metabolism
Animals
Aspartic Acid Endopeptidases
Axin Protein
Cyclin D1
Cytoskeletal Proteins--metabolism
Cytosol
DNA-Binding Proteins--metabolism
Endopeptidases--metabolism
Fibroblasts--cytology
Gene Expression Regulation
Lymphoid Enhancer-Binding Factor 1
Membrane Proteins--genetics
Mice
Mutation
Presenilin-1
Protein Processing, Post-Translational
Proteins--metabolism
Receptor, Notch1
Receptors, Cell Surface
Repressor Proteins
S Phase
Signal Transduction
Trans-Activators
Transcription Factors--metabolism
Ubiquitins--metabolism
Wnt Proteins
Wnt3 Protein
beta Catenin