Mitogenic effect of oxidized low-density lipoprotein on vascular smooth muscle cells mediated by activation of Ras/Raf/MEK/MAPK pathway.

Yang, C M

Mitogenic effect of oxidized low-density lipoprotein on vascular smooth muscle cells mediated by activation of Ras/Raf/MEK/MAPK pathway. [electronic resource] - British journal of pharmacology Apr 2001 - 1531-41 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0007-1188

10.1038/sj.bjp.0703976 doi


Animals
Benzoquinones
Calcium--pharmacology
DNA--biosynthesis
Dose-Response Relationship, Drug
Enzyme Activation--drug effects
Enzyme Inhibitors--pharmacology
Estrenes--pharmacology
Flavonoids--pharmacology
Genistein--pharmacology
Humans
Lactams, Macrocyclic
Lipoproteins, LDL--pharmacology
MAP Kinase Signaling System--drug effects
Mitogen-Activated Protein Kinase 1--drug effects
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinases--drug effects
Mitogens--pharmacology
Muscle, Smooth, Vascular--cytology
Pertussis Toxin
Phosphorylation--drug effects
Protein Kinase C--antagonists & inhibitors
Protein-Tyrosine Kinases--antagonists & inhibitors
Proto-Oncogene Proteins c-raf--metabolism
Pyrrolidinones--pharmacology
Quinones--pharmacology
Rats
Rats, Sprague-Dawley
Rifabutin--analogs & derivatives
Staurosporine--pharmacology
Virulence Factors, Bordetella--pharmacology
ras Proteins--metabolism