Dipeptidyl peptidase IV is a target for covalent adduct formation with the acyl glucuronide metabolite of the anti-inflammatory drug zomepirac.

Wang, M

Dipeptidyl peptidase IV is a target for covalent adduct formation with the acyl glucuronide metabolite of the anti-inflammatory drug zomepirac. [electronic resource] - Life sciences Jan 2001 - 785-97 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0024-3205

10.1016/s0024-3205(00)00981-4 doi


Animals
Anti-Inflammatory Agents, Non-Steroidal--metabolism
Blotting, Western
CHO Cells
Cricetinae
DNA Adducts--metabolism
Dipeptidyl Peptidase 4--metabolism
Glucuronides--metabolism
Humans
Hydrogen-Ion Concentration
Liver--enzymology
Male
Precipitin Tests
Rats
Rats, Sprague-Dawley
Recombinant Proteins--chemistry
Tolmetin--analogs & derivatives