Pharmacokinetics of orally administered camptothecins.

Gupta, E

Pharmacokinetics of orally administered camptothecins. [electronic resource] - Annals of the New York Academy of Sciences 2000 - 195-204 p. digital

Publication Type: Journal Article

0077-8923

10.1111/j.1749-6632.2000.tb07038.x doi


Administration, Oral
Anion Transport Proteins
Antineoplastic Agents, Phytogenic--pharmacokinetics
Biological Transport, Active--drug effects
Biotransformation
Caco-2 Cells--metabolism
Camptothecin--analogs & derivatives
Carrier Proteins--antagonists & inhibitors
Cell Membrane Permeability
Colonic Neoplasms--metabolism
Enzyme Inhibitors--pharmacokinetics
Humans
Hydrolysis
Intestinal Absorption--drug effects
Intestinal Mucosa--metabolism
Irinotecan
Liver--metabolism
Liver Neoplasms--metabolism
Probenecid--pharmacology
Prodrugs--pharmacokinetics
Rectal Neoplasms--metabolism