Lovastatin induces apoptosis of spontaneously immortalized rat brain neuroblasts: involvement of nonsterol isoprenoid biosynthesis inhibition.

García-Román, N

Lovastatin induces apoptosis of spontaneously immortalized rat brain neuroblasts: involvement of nonsterol isoprenoid biosynthesis inhibition. [electronic resource] - Molecular and cellular neurosciences Feb 2001 - 329-41 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1044-7431

10.1006/mcne.2000.0904 doi


Animals
Anticholesteremic Agents--pharmacology
Apoptosis--drug effects
Carrier Proteins--metabolism
Cell Division--drug effects
Cell Line, Transformed
Cholesterol--pharmacology
Lovastatin--pharmacology
Mevalonic Acid--pharmacology
Neurons--cytology
Polyisoprenyl Phosphates--biosynthesis
Pravastatin--pharmacology
Protein Prenylation--drug effects
Proto-Oncogene Proteins--metabolism
Proto-Oncogene Proteins c-bcl-2--metabolism
Rats
Sesquiterpenes
Squalene--pharmacology
Stem Cells--cytology
bcl-2-Associated X Protein
bcl-Associated Death Protein
bcl-X Protein