Grb2 downregulation leads to Akt inactivation in heregulin-stimulated and ErbB2-overexpressing breast cancer cells.

Lim, S J

Grb2 downregulation leads to Akt inactivation in heregulin-stimulated and ErbB2-overexpressing breast cancer cells. [electronic resource] - Oncogene Dec 2000 - 6271-6 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

0950-9232

10.1038/sj.onc.1204014 doi


Adaptor Proteins, Signal Transducing
Breast Neoplasms--genetics
Cell Division--drug effects
Down-Regulation
Female
GRB2 Adaptor Protein
Humans
Liposomes--administration & dosage
Neuregulin-1--genetics
Oligodeoxyribonucleotides, Antisense--pharmacology
Protein Serine-Threonine Kinases
Proteins--genetics
Proto-Oncogene Proteins--metabolism
Proto-Oncogene Proteins c-akt
Receptor, ErbB-2--genetics
Transfection
Tumor Cells, Cultured