Mice with a partial deficiency of manganese superoxide dismutase show increased vulnerability to the mitochondrial toxins malonate, 3-nitropropionic acid, and MPTP.

Andreassen, O A

Mice with a partial deficiency of manganese superoxide dismutase show increased vulnerability to the mitochondrial toxins malonate, 3-nitropropionic acid, and MPTP. [electronic resource] - Experimental neurology Jan 2001 - 189-95 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.

0014-4886

10.1006/exnr.2000.7525 doi


1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
3,4-Dihydroxyphenylacetic Acid--metabolism
Animals
Carrier Proteins--metabolism
Corpus Striatum--drug effects
Disease Models, Animal
Dopamine--metabolism
Dopamine Plasma Membrane Transport Proteins
Female
Genetic Predisposition to Disease--genetics
Gentisates
Heterozygote
Homovanillic Acid--metabolism
Hydroxybenzoates--metabolism
Hydroxyl Radical--metabolism
Male
Malonates
Membrane Glycoproteins
Membrane Transport Proteins
Mice
Mice, Knockout
Mitochondria--drug effects
Nerve Tissue Proteins
Neurodegenerative Diseases--chemically induced
Neurotoxins--metabolism
Nitro Compounds
Propionates
Salicylic Acid--metabolism
Superoxide Dismutase--deficiency