SB 239063, a second-generation p38 mitogen-activated protein kinase inhibitor, reduces brain injury and neurological deficits in cerebral focal ischemia.

Barone, F C

SB 239063, a second-generation p38 mitogen-activated protein kinase inhibitor, reduces brain injury and neurological deficits in cerebral focal ischemia. [electronic resource] - The Journal of pharmacology and experimental therapeutics Feb 2001 - 312-21 p. digital

Publication Type: Journal Article

0022-3565


Animals
Anti-Inflammatory Agents, Non-Steroidal--therapeutic use
Body Temperature--drug effects
Brain--pathology
Cerebrovascular Circulation--drug effects
Enzyme Inhibitors--therapeutic use
Hemodynamics--drug effects
Hippocampus--pathology
Imidazoles--therapeutic use
Inflammation--pathology
Ischemic Attack, Transient--drug therapy
Mitogen-Activated Protein Kinases--antagonists & inhibitors
Neuroprotective Agents--therapeutic use
Organ Culture Techniques
Pyridines--therapeutic use
Pyrimidines--therapeutic use
Rats
Rats, Inbred Lew
Rats, Inbred SHR
p38 Mitogen-Activated Protein Kinases