Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence.

Bohn, L M

Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence. [electronic resource] - Nature Dec 2000 - 720-3 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0028-0836

10.1038/35047086 doi


Adenylyl Cyclases--metabolism
Analgesics, Opioid--pharmacology
Animals
Arrestins--physiology
Brain Stem--metabolism
Drug Implants
Drug Tolerance
GTP-Binding Proteins--metabolism
Guanosine 5'-O-(3-Thiotriphosphate)--metabolism
Membranes--metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
Morphine--pharmacology
Morphine Dependence--metabolism
Mutation
Receptors, Opioid, mu--metabolism
beta-Arrestin 2
beta-Arrestins