Synthesis and pharmacological evaluation of thiopyran analogues of the dopamine D3 receptor-selective agonist (4aR,10bR)-(+)-trans-3,4,4a,10b-tetrahydro-4-n-propyl-2H,5H [1]b enzopyrano[4,3-b]-1,4-oxazin-9-ol (PD 128907).
van Vliet, L A
Synthesis and pharmacological evaluation of thiopyran analogues of the dopamine D3 receptor-selective agonist (4aR,10bR)-(+)-trans-3,4,4a,10b-tetrahydro-4-n-propyl-2H,5H [1]b enzopyrano[4,3-b]-1,4-oxazin-9-ol (PD 128907). [electronic resource] - Journal of medicinal chemistry Jul 2000 - 2871-82 p. digital
Publication Type: Journal Article
0022-2623
10.1021/jm0000113 doi
Animals
Benzopyrans--chemical synthesis
Binding, Competitive
CHO Cells
Corpus Striatum--metabolism
Cricetinae
Crystallography, X-Ray
Cyclic S-Oxides--chemical synthesis
Dopamine--metabolism
Dopamine Agonists--chemical synthesis
Male
Microdialysis
Morpholines--chemical synthesis
Motor Activity--drug effects
Oxazines--chemical synthesis
Radioligand Assay
Rats
Rats, Wistar
Receptors, Dopamine D2--agonists
Receptors, Dopamine D3
Receptors, Serotonin--drug effects
Receptors, Serotonin, 5-HT1
Serotonin Receptor Agonists--chemical synthesis
Stereoisomerism
Structure-Activity Relationship
Synthesis and pharmacological evaluation of thiopyran analogues of the dopamine D3 receptor-selective agonist (4aR,10bR)-(+)-trans-3,4,4a,10b-tetrahydro-4-n-propyl-2H,5H [1]b enzopyrano[4,3-b]-1,4-oxazin-9-ol (PD 128907). [electronic resource] - Journal of medicinal chemistry Jul 2000 - 2871-82 p. digital
Publication Type: Journal Article
0022-2623
10.1021/jm0000113 doi
Animals
Benzopyrans--chemical synthesis
Binding, Competitive
CHO Cells
Corpus Striatum--metabolism
Cricetinae
Crystallography, X-Ray
Cyclic S-Oxides--chemical synthesis
Dopamine--metabolism
Dopamine Agonists--chemical synthesis
Male
Microdialysis
Morpholines--chemical synthesis
Motor Activity--drug effects
Oxazines--chemical synthesis
Radioligand Assay
Rats
Rats, Wistar
Receptors, Dopamine D2--agonists
Receptors, Dopamine D3
Receptors, Serotonin--drug effects
Receptors, Serotonin, 5-HT1
Serotonin Receptor Agonists--chemical synthesis
Stereoisomerism
Structure-Activity Relationship