Induction of cyclooxygenase-2 by platelet-derived growth factor (PDGF) and its inhibition by dexamethasone are independent of NF-kappaB/IkappaB transcription factors.

Goppelt-Struebe, M

Induction of cyclooxygenase-2 by platelet-derived growth factor (PDGF) and its inhibition by dexamethasone are independent of NF-kappaB/IkappaB transcription factors. [electronic resource] - Naunyn-Schmiedeberg's archives of pharmacology Jun 2000 - 636-45 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0028-1298

10.1007/s002100000231 doi


Animals
Cells, Cultured
Cycloheximide--pharmacology
Cyclooxygenase 2
DNA--metabolism
Dactinomycin--pharmacology
Dexamethasone--pharmacology
Enzyme Induction
Gene Expression Regulation, Enzymologic
Genes, Reporter
I-kappa B Proteins--genetics
Isoenzymes--biosynthesis
Kidney Glomerulus--cytology
NF-kappa B--genetics
Nucleic Acid Synthesis Inhibitors--pharmacology
Platelet-Derived Growth Factor--pharmacology
Prostaglandin-Endoperoxide Synthases--biosynthesis
Protein Synthesis Inhibitors--pharmacology
RNA, Messenger--genetics
Rats
Transcriptional Activation